Midlands Extracellular Vesicles Network

Extracellular vesicles

Mission: Midlands Extracellular Vesicles Network (MEVN) is a joint partnership across the 7 Midlands Innovation Health institutions which aims to:

  1. Develop a vibrant multidisciplinary research community, bringing focus to the diverse Extracellular Vesicle (EV) research activity in the Midlands both academic and industrial.
  2. Facilitate inter-disciplinary and inter-sectoral research collaborations, to develop the next generation of EV based research programmes.
  3. Share best practice and provide a platform for collaborative rather than competitive bids, strengthening submissions to research councils for funding.
  4. Train, support and inspire the next generation of outstanding leaders in EV research.

Collaboration: The partnership structure comprises a senior and early career researcher from each institution:

   Aston University: Professor Andrew Devitt
   University of Birmingham: Dr Joshua Price
   Keele University: Dr Oksana Kehoe and Dr Nicholas Wragg
   University of Leicester: Professor Galina Mukamolova
   Loughborough University: Dr Owen Davies and Dr Soraya Williams
   University of Nottingham: Professor Lucy Fairclough (CHAIR) and Dr Hannah Jackson
   University of Warwick: Professor Dimitris Grammatopoulos and Dr Darius Koester

Support colleagues: Alex Archibald (MI Health), Ellen McGhee (MI) and Matt Vassey (Aston University).

Events: On 21st September 2023, MEVN held an inaugural (half day) virtual conference focussed on ‘Health and Inflammation’. This provided an opportunity for presentations, discussions, and conversations around this exciting and growing area of EV research. To watch recordings from this event click here.

MEVN is looking to run a series of virtual and in-person events. We anticipate these meetings will evolve in content, theme and location as the network grows and would love to engage the community around this as we move forwards. If you are interested in being involved, please get in touch.

Midlands Strengths and Capabilities Catalogue
Biology
Biogenesis and secretion Nottingham
Cell death Aston
Communication and signalling (intercellular and extracellular) Aston, Nottingham
Complex biofluids Birmingham
Endothelial cells Aston
Epithelial cells Nottingham
Genome stability Aston
Immune-modulation Aston
Immune cells Nottingham
Lipidomics Aston
Membranes – biophysics and models Aston
Metabolomics Aston
Molecular biology Nottingham
Platelet-derived microvesicles Aston
Proteomics Aston, Birmingham, Nottingham
Redox biology Aston
RNA Birmingham, Nottingham
Stem cells Aston, Keele, Nottingham
Synthetic and semi-synthetic EVs Aston
T cells Keele
Trypanosomes genetics Warwick
Applications
Ageing Aston
Bioinformatics Birmingham
Biomarkers Aston
Cardiovascular disease Aston
Cancer and cancer therapies Aston, Birmingham, Nottingham
Dermatology Loughborough
Disease pathophysiology, prognosis, and outcomes Aston, Birmingham
Drug discovery Aston
DNA damage responses Aston
Exercise and metabolism Birmingham
Hypoxia/normoxia effects Keele
Inflammation, allergy and allergic sensitisation Aston, Keele, Nottingham, Warwick
Lung disease, respiratory infections, COPD, cystic fibrosis and IPF Keele, Nottingham
Maternity Warwick
Musculoskeletal Birmingham, Keele, Loughborough
Nanotechnology Aston
Neurology Aston, Nottingham
Regenerative Medicine Aston, Keele
Therapeutics Loughborough
Wound healing Aston, Keele
Virology Keele
Methods
Animal models Aston, Keele, Nottingham
Assays Aston, Birmingham, Loughborough, Nottingham
Biophysical methods Aston
Cell cycle analysis Aston
Cell growth and cultures Aston, Keele, Nottingham, Warwick
Centrifugation Birmingham, Keele, Nottingham, Loughborough
Confocal microscopy Aston
Cryo-TEM Keele
DNA repair foci analysis Aston
ELISAs Keele
Extraction Birmingham, Keele
Flow cytometry Aston, Keele, Nottingham
Freeze-drying Keele
Immunopurification Loughborough
Live cell imaging Aston
Lumi-aggregometry Aston
Manufacturing and storage Keele
Mass Spectrometry Aston, Birmingham, Keele, Nottingham
Microscopy Aston, Nottingham, Warwick
Molecular cloning Nottingham
Nano Flow Cytometry Aston, Keele
Nanoparticle tracking analysis Birmingham, Nottingham
Next-generation sequencing Keele, Nottingham
Pathway in vitro reconstitutions Aston
Precipitation Loughborough
Pulse-field gel electrophoresis Aston
Polymerase chain reaction Birmingham, Nottingham
RNA probes Nottingham
Size exclusion chromatography Aston, Birmingham, Keele, Loughborough, Nottingham
Tangential flow filtration Aston, Loughborough
Tunable resistive pulse-sensing Aston
Ultrafiltration Loughborough
Western blot Aston, Birmingham, Keele, Loughborough, Nottingham, Warwick
X-ray irradiation Aston
Equipment
3000 Dionex RS online coupled to 5500 Sciex QTrap Aston
5600 Triple Tof Aston
ABSciex 5500 Aston
Agilent Biotek Gen 5 Aston
Baker Ruskinn InvivO2 Physiological Cell Culture Workstation Keele
BD Accuri C6 Plus Aston
BD Biosciences FACS Canto II cytometer Keele
Beckman-Coulter Cytoflex Birmingham, Keele
Beckman-Coulter Cytoflex S Aston
Beckman Coulter L8-M Ultracentrifuge Keele
Beckman Coulter Optima TLX Ultracentrifuge Birmingham
Beckman Coulter Optima XPN 80 – IVD Ultracentrifuge Keele
Bio-Rad pulse field gel electrophoresis system Aston
Christ 1-2 LD plus Keele
Chronolog Model 700 Aston
FUJJIFILM Wako MagCapture Exosome Isolation Kit PS Ver.2 Warwick
Haematology analyser Aston
Hypoxycool unit Keele
Izon automated fraction collectors Aston, Birmingham
Izon Exoid Aston, Birmingham
Litesizer 500 for DLS Warwick
Leica confocal microscopy Keele
Malvern LM10, NS300, NS Pro Birmingham
Miltenyi MACSPlex exosome kit Keele
Miltenyi Biotec EV Isolation Kit Pan, human Warwick
Multi-omics on Ascend Tribrid MS Aston
NanoFCM Nanoanalyse Aston
Nanolive Explorer tomographic microscope Aston
Nikon fluorescent microscope Aston
Protein purification chromatography systems Aston
Thermo Scientific™ Q Exactive™ HF-X Birmingham
QIAGEN exoEasy Maxi Kit Warwick
Quantum™ Cell Expansion System Keele
Unchained Lab Leprechaun/ExoView R100 Birmingham
Waters M class online coupled to 5600 Sciex TropleTof Aston
*Birmingham also have ImageStream and ONI but there are no EV trained individuals

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